Journal of controlled release : official journal of the Controlled Release SocietyAnimalsVitamin ECancer VaccinesOleic AcidLipids
Combination of ionizable lipids with oleic acid and vitamin E scaffolds for RNA cancer vaccine delivery.
Jessica Anindita, Hiroki Tanaka, Ryotaro Oyama, Atsuya Matsumaru, Yuta Nakai, Kota Tange, Koji Nagaoka, Hideyuki Nakanishi, Takeshi Kawamura, Toshiya Tanaka, Takefumi Yamashita, Akihiro Kuroda, Sachiyo Nomura, Hiroto Hatakeyama, Keiji Itaka
Published: 202610.1016/j.jconrel.2025.114414
Abstract
RNA vaccines based on lipid nanoparticles (LNPs) encapsulating in vitro transcribed mRNA (IVT-mRNA) are a successful but evolving vaccine modality. It has been increasingly recognized that LNPs, which are mainly composed of ionizable lipids, have two…
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