Journal of controlled release : official journal of the Controlled Release SocietyHumansAnimalsT-LymphocytesImmunotherapyAdoptive
In vivo nano-engineering T cells for CAR-T therapy.
Tianyu Shi, Yao Li, Changchang Deng, Qiongzhe Ren, Congcong Xu, Zhiyuan Zhong
Published: 202510.1016/j.jconrel.2025.114379
Abstract
In vivo nano-engineering of T cells has moved from a delivery question to an integrated framework that combines targeting, exposure, and expression to build CAR T therapies within patients. We distill the design rules of active targeting on viral and…
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