Journal of controlled release : official journal of the Controlled Release SocietyAnimalsHumansCD8-Positive T-LymphocytesNanoparticlesMice
ApoE2-DARPin fusion proteins enable selective RNA transfer to CD8 T cells by lipid nanoparticles.
Samuel A Theuerkauf, Luca J Zinser, Nandini Sheth, Elham Adabi, Lea R Knapp, Johanna M Gorol, Sascha Hein, Angeliki Chroni, Frederic B Thalheimer, Christian J Buchholz
Published: 202510.1016/j.jconrel.2025.114377
Abstract
Lipid nanoparticles (LNPs) have emerged as important tool to deliver therapeutic agents into cells. RNA-LNP vaccines demonstrated safety and efficacy during the COVID-19 pandemic and thereby boosted LNP technology for gene delivery. However, RNA-LNPs…
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