Journal of controlled release : official journal of the Controlled Release SocietyAnimalsHumansPolylysineMiceHydrogen Bonding
Thiourea-modified poly(l-lysine) carriers with multiple hydrogen bonding interactions for safe and robust mRNA vaccine therapy.
Jiangai Long, Sheng Ma, Renming Wan, Aolin Sun, Zhenyi Zhu, Ruoyi Wang, Zhaopei Guo, Wantong Song
Published: 202510.1016/j.jconrel.2025.114371
Abstract
Cationic polymers have garnered considerable attention as mRNA carriers due to their structural tunability and chemical diversity. Nevertheless, their broader application remains limited by poor stability under physiological conditions and cytotoxici…
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