Journal of controlled release : official journal of the Controlled Release SocietyCarcinomaNon-Small-Cell LungLung NeoplasmsAnimalsHumans
Hybrid nanovesicles enhance antitumor efficacy in KRAS-mutant non-small cell lung cancer.
Huan Yang, Lin Hu, Zhiyue Su, Fei Peng, Yuhong Wang, Chang Qi, Wenhao Shen, Kai Yang, Jun Zhao, Lingchuan Guo, Zhe Lei
Published: 202510.1016/j.jconrel.2025.114345
Abstract
KRAS mutations are key drivers of NSCLC, but effective targeted therapies remain scarce due to frequent resistance. EGFR phosphorylation has emerged as a central mechanism underlying acquired resistance to KRAS inhibitors. To overcome this, we develo…
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