Journal of controlled release : official journal of the Controlled Release SocietySpinal Cord InjuriesAnimalsLiposomesRosuvastatin CalciumMice
Engineered lesion-homing liposomes encapsulating Rosuvastatin enhance spinal cord injury repair by preventing the formation of foamy macrophages.
Zhide Liu, Jinyun Zhao, Haicheng Wen, Yiming Qin, Lifu Zheng, Yi Sun, Rundong He, Aozhuo Zu, Tianding Wu, Liyuan Jiang, Hongbin Lu, Jianzhong Hu, Yong Cao, Chunyue Duan
Published: 202510.1016/j.jconrel.2025.114308
Abstract
Following spinal cord injury (SCI), infiltrating macrophages excessively phagocytose myelin debris, subsequently transforming into foamy macrophages that significantly exacerbate secondary injury pathology. In this study, we developed cysteine-alanin…
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