Journal of controlled release : official journal of the Controlled Release SocietyPolyethylene GlycolsChelating AgentsAnimalsHumansCell Line
Control of pharmacokinetics of radioimmunoconjugates using chelating agents containing poly(ethylene glycol).
Kazuma Nakashima, Hiroki Jinda, Hiroki Shimohara, Hiroyuki Watanabe, Masahiro Ono
Published: 202510.1016/j.jconrel.2025.114293
Abstract
Radioimmunoconjugates (RICs) composed of a monoclonal antibody (mAb) and radioisotope (RI) offer an attractive modality in oncology; however, their low tumor/blood ratio has limited their utility. To establish a novel strategy to improve the tumor/bl…
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