Journal of controlled release : official journal of the Controlled Release SocietyMaleProstatic NeoplasmsAnimalsOxidative StressPolyamines
Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer.
Aijing Zhang, Jianguo Zheng, Yingying Xu, Shuai Fu, Qinglong Du, Chengyang Zhao, Yuxiang Meng, Mengqi Li, Lin Wang, Shuliang Wang, Tongrui Shi, Chen Yang, Peihong Jiang, Yiping Wang, Zhongwei Zhao
Published: 202510.1016/j.jconrel.2025.114283
Abstract
Immunotherapy of prostate cancer (PCa) remains challenging due to the immunosuppressive nature of the tumor microenvironment (TME). Oxidative damage enhances immunogenic cell death (ICD) to counteract immunotherapy resistance in PCa, but is limited b…
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