Journal of controlled release : official journal of the Controlled Release SocietyAnimalsFibrosisPancreasPancreatic Stellate CellsCollagen
Fibrotic collagen-targeted delivery system blocks pancreatic intercellular crosstalk to alleviate pancreatic fibrosis.
Hui Wang, Liang Qi, Yue-Fei Fang, Yang Liu, Zheng Ye, Bi-Te Chen, Yi Wang, Hu-Lin Jiang, Ling Li
Published: 202510.1016/j.jconrel.2025.114278
Abstract
Pancreatic fibrosis (PF) is a significant disruption of homeostasis in the pancreas, primarily characterized by excessive extracellular matrix (ECM) deposition due to pancreatic acinar cell (PAC) injury, pancreatic stellate cell (PSC) activation, and…
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