Cellular and molecular gastroenterology and hepatology
The P2X7 Receptor Promotes Intestinal Fibrosis by Modulating the Gut Microbiota and the Inflammasome.
Beatriz Elias Ribeiro, Isadora Schmukler de Lima, Karen Cristina da Silva E Souza, Siane Lopes Bittencourt Rosas, Patrícia Teixeira Santana, Gilda Amaral, João Carlos Machado, Rodrigo Pereira de Oliveira, Camille Leal, Cristiane Thompson, Fabiano Thompson, Morgana Teixeira Lima Castelo-Branco, Robson Coutinho-Silva, Heitor Siffert Pereira de Souza
Published: 202510.1016/j.jcmgh.2025.101718
Abstract
BACKGROUND & AIMS: Considering the role of the P2X7 receptor in intestinal inflammation, we examined its potential involvement in fibrosis development. METHODS: Colonic biopsies from patients with inflammatory bowel disease (IBD) were analyzed via do…
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