Cellular and molecular gastroenterology and hepatology
Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes.
Michael S Poslusney, Qian Li, Ingrid P Buchler, Yifang Huang, Liansheng Liu, Yaohui Zhu, Subhash Kulkarni, Gregory Carr, Adrienne DeBrosse, Noelle White, Diane Peters, James C Barrow, Pankaj J Pasricha
Published: 202610.1016/j.jcmgh.2025.101704
Abstract
BACKGROUND & AIMS: Visceral pain is a cardinal symptom of many disorders affecting the gut and other abdominal organs. Modulators of gamma-aminobutyric acid (GABA) such as benzodiazepines may attenuate such pain but the specific contribution of perip…
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