Journal of clinical epidemiologyRandomized Controlled Trials as TopicHumansCluster AnalysisResearch Design
A scoping review identified additional considerations for defining estimands in cluster randomized trials.
Dongquan Bi, Andrew Copas, Fan Li, Brennan C Kahan
Published: 202610.1016/j.jclinepi.2025.112015
Abstract
OBJECTIVES: An estimand is a clear description of the treatment effect a study aims to quantify. The ICH E9(R1) addendum lists five attributes that should be described when defining an estimand. However, the addendum was primarily developed for indiv…
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