Journal of clinical epidemiologyHumansRandomized Controlled Trials as TopicTherapeutic EquipoiseNeoplasmsModels
Theory of clinical therapeutic progress: reconciling equipoise with fat-tailed (skewed) outcomes.
Iztok Hozo, Benjamin Djulbegovic
Published: 202510.1016/j.jclinepi.2025.112004
Abstract
OBJECTIVE: Randomized controlled trials (RCTs) embody a paradox: they require equipoise-genuine uncertainty about treatment effects-to ethically protect participants, yet this very requirement can slow therapeutic innovation by discouraging trials of…
Preview only. Read the full abstract at the source