Journal of clinical epidemiologyBayes TheoremHumansRandomized Controlled Trials as TopicSample SizeAsthma
A Bayesian framework to evaluate non-inferiority in randomized controlled trials of uncommon conditions.
Victoria R Cornelius, Jack Elkes, Ian R White, Rebecca M Turner, Michelle Clements, Matteo Quartango, Conor D Tweed, Sejal Saglani, Suzie Cro
Published: 202610.1016/j.jclinepi.2025.112002
Abstract
BACKGROUND AND OBJECTIVES: Noninferiority (NI) trials typically require larger sample sizes than superiority comparisons. This is problematic for uncommon conditions where recruitment is restricted. When a power calculation results in an unfeasibly l…
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