Journal of colloid and interface scienceMetal-Organic FrameworksAnimalsMiceHumansAntineoplastic Agents
Self-amplifying hypoxia cascade in covalent organic framework/metal organic framework nanoreactors for synergistic cancer therapy.
Chengcai He, Ye Zhang, Xiaozhen Liu, Chengmu Yu, Jie Lv, Yulong Lin, Lianmei Zhao, Meng Li
Published: 202610.1016/j.jcis.2025.139602
Abstract
Tumor hypoxia, a hallmark of the tumor microenvironment (TME), drives malignancy and therapeutic resistance but also offers a target for selective therapy. Hypoxia-activated prodrugs (HAPs) like TH-302 exploit this niche, yet their efficacy is often…
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