Journal of chromatography. B, Analytical technologies in the biomedical and life sciencesHumansHigh-Throughput Nucleotide SequencingImmunomagnetic SeparationLeukocyte Common AntigensMetagenomics
Development and evaluation of CD45-conjugated magnetic particles-based host cell depletion for enhanced metagenomic next-generation sequencing in bloodstream infection.
Weiwei Wu, Jingjing Song, Qiuyue Wu, Xin Wu, Ning Sun, Xinyi Xia
Published: 202510.1016/j.jchromb.2025.124823
Abstract
Metagenomic next-generation sequencing (mNGS) enables unbiased detection of human pathogens without prior assumptions. However, the direct detection of bloodstream infection pathogens is limited by host DNA interference, leading to the clinical adopt…
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