Journal of biotechnologyEscherichia coliAminolevulinic AcidPlasmidsMetabolic EngineeringProbiotics
Engineering of endogenous plasmids in probiotic Escherichia coli Nissle 1917 for autonomous accumulation of 5‑aminolevulinic acid.
Dong Yu, Lin Zhu, Ya-Xue Ding, Li-Jing Mao, Min Xiong, Xiao-Xuan Jin, Yujie Ma, Feng-Qing Wang, Liang-Bin Xiong
Published: 202610.1016/j.jbiotec.2025.11.006
Abstract
5-aminolevulinic acid (ALA), a non‑proteinogenic δ‑amino acid, is a versatile compound with applications as a tumor-sensitizing agent in photodynamic therapy and a plant biostimulant that enhances stress tolerance and photosynthetic efficiency. This…
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