Modular engineering of the doxorubicin biosynthetic gene cluster based on component functional clustering in Streptomyces.

The anticancer drug doxorubicin is synthesized through the synergistic action of the type II polyketide synthases, along with an array of modification enzymes in Streptomyces. The 33 doxorubicin biosynthetic genes are scattered across at least 15 dis…

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