Advances in biological regulation
The AP-4 accessory protein tepsin exhibits multivalent binding to LC3B.
Cameron I Cohen, Amy K Kendall, Natalie S Wallace, Maggie L McCorkle, Lauren P Jackson
Published: 202510.1016/j.jbior.2025.101124
Abstract
Tepsin is an accessory protein in Adaptor Protein 4 (AP-4) coated vesicles responsible for trafficking cargo from the trans-Golgi network (TGN). AP-4 vesicles recognize and sort multiple cargoes including ATG9A, a lipid scramblase essential for autop…
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