The Journal of biological chemistry
The protease Cathepsin K can debulk the cancer glycocalyx.
Angel Kuo, Gabrielle S Tender, William D Chow, Nicholas M Riley, Ke Chloe Wen, Sangwoo Park, Justin H Paek, David S Roberts, Egan L Peltan, Matthew J Paszek, Carolyn R Bertozzi
Published: 202610.1016/j.jbc.2026.111206
Abstract
The cancer glycocalyx is characterized by the overexpression of large glycoconjugates, including mucins, proteoglycans, and polysialic acid, which collectively increase glycocalyx thickness and stiffness to promote tumor survival, metastasis, and pro…
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