The Journal of biological chemistry
Nitric Oxide Mediates ET-1-induced-Inhibition of NPPB-Sensitive Cl- Currents in Early Distal Convoluted Tubule of the Mouse Kidney.
Lixia Hu, Hao Zhang, Ao Xiao, Haiwen Qiu, Xinxin Meng, Yi You, Mingxiao Wang
Published: 202610.1016/j.jbc.2026.111202
Abstract
Endothelin-1 (ET-1) from renal-tubule-epithelial-cells inhibits NaCl reabsorption via ETB receptor in an autocrine manner and inhibition of ETB receptors leads to salt-sensitive-hypertension. In the distal-convoluted-tubule (DCT), NaCl enters the cel…
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