The Journal of biological chemistry
Activated protein C drives β-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5.
Huaping Qin, Lennis B Orduña-Castillo, Olivia Molinar-Inglis, Monica L Gonzalez Ramirez, Miguel A Lopez-Ramirez, Carolyne Bardeleben, JoAnn Trejo
Published: 202610.1016/j.jbc.2026.111190
Abstract
G protein-coupled receptors (GPCRs) display bias towards either G proteins or GPCR kinase (GRK)-mediated β-arrestin signaling depending on the agonist stabilized receptor conformation. The cellular context and subcellular location of GPCRs can also i…
Preview only. Read the full abstract at the source