The Journal of biological chemistry
Photodynamic activation of a KRAS RNA G-quadruplex-targeted photosensitizer induces ferroptosis in cisplatin-resistant non-small cell lung cancer.
Xiao-Dong Wang, Jia-Hong Lin, Ming-Hao Hu
Published: 202610.1016/j.jbc.2026.111181
Abstract
KRAS overactivation plays a crucial role in the development of non-small cell lung cancer (NSCLC). Although two KRAS inhibitors have been approved for NSCLC treatment, their efficacy is limited to the KRAS G12C mutant along with the occurrence of dru…
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