The Journal of biological chemistry
Palmitic acid induces UCP1-independent mitochondrial depolarization specifcally in brown adipose tissue.
Yuto Ishikawa, Isshin Shiiba, Eisho Kozakura, Haruto Yabu, Shun Hirose, Hijiri Oshio, Ken-Ichi Yamada, Yuko Okamatsu-Ogura, Ryoko Inatome, Shigeru Yanagi
Published: 202610.1016/j.jbc.2026.111177
Abstract
Brown adipose tissue (BAT) is a major site of non-shivering thermogenesis, where mitochondria generate heat instead of adenosine triphosphate (ATP). The thermogenesis occurs through the activity of uncoupling protein 1 (UCP1) which specifically resid…
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