The Journal of biological chemistry
Deficient mitochondrial tRNA modifications arising from TRMU mutation led to the liver-specific failure.
Xiao He, Qinghai Zhang, Chao Chen, Yutao Wu, Kai Wang, Shihao Yao, Haiyan Sun, Min-Xin Guan
Published: 202610.1016/j.jbc.2026.111168
Abstract
Posttranscriptional nucleotide modifications of tRNAs play the critical roles in their structure and function. Deficient τm5s2U modifications of mitochondrial tRNAGlu, tRNAGln and tRNALys arising from TRMU mutations primarily manifest the liver failu…
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