The Journal of biological chemistry
Loss of ATM causes R-loop-associated transcriptional dysregulation and attenuates the related response to DNA damage.
Katherine R Westover, Yingzi Hou, Feng Wang, Yilin Wang, Yangping Li, Rachel Seong, Jie Xu, Zhexing Wen, Bing Yao
Published: 202610.1016/j.jbc.2026.111161
Abstract
An early childhood onset neurodegenerative disorder, Ataxia Telangiectasia (AT) affects 1 in 40,000 to 100,000 individuals worldwide and is caused by mutations in the ataxia telangiectasia mutated (ATM) threonine-serine kinase, which regulates the DN…
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