The Journal of biological chemistry
F2,6BP restores mitochondrial genome integrity in Huntington's Disease.
Anirban Chakraborty, Santi M Mandal, Mikita Mankevich, Rajam S Mani, Shandy Shahabi, Manohar Kodavati, Sravan Gopalkrishnashetty Sreenivasmurthy, Nisha Tapryal, Dale J Hamilton, Balaji Krishnan, Muralidhar L Hegde, Michael Weinfeld, Gourisankar Ghosh, Tapas Hazra
Published: 202610.1016/j.jbc.2026.111156
Abstract
Several reports have indicated that impaired mitochondrial function contributes to the development and progression of Huntington's disease (HD). Mitochondrial genome damage, particularly DNA strand breaks, is a potential cause for its compromised fun…
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