The Journal of biological chemistry
HMGB1 Binds to and Disrupts the Hairpin Structure of RNA15 and Inhibits Toll-like Receptor Activation.
Cong Lin, Penghui Li, Anna G Savitskaya, Ekaterina Lyukmanova, Sergey A Goncharuk, Konstantin S Mineev, Xiubo Du, Yibo Wang, Xiaohui Wang
Published: 202610.1016/j.jbc.2026.111155
Abstract
Toll-like receptor 13 (TLR13) is a critical innate immune sensor that recognizes a conserved RNA sequence, RNA15 (2054-2068, ACG GAA AGA CCC CGU), within bacterial 23S rRNA, thereby initiating a pro-inflammatory response. While the alarmin high mobil…
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