The Journal of biological chemistry
Effect of pH on small-molecule inhibitor binding to influenza virus hemagglutinin.
Varada Anirudhan, Irina Gaisina, Amir Shimon, Hyun Lee, Saad Alqarni, Balaji Manicassamy, Terry W Moore, Kai Xu, Michael Caffrey, Lijun Rong
Published: 202610.1016/j.jbc.2026.111150
Abstract
Influenza A viruses (IAVs) impose a tremendous socio-economic burden and the mainstay preventative strategy of using vaccines faces challenges related to annual reformulation and variable efficacy (30-70%). The occurrence of antiviral resistance to t…
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