The Journal of biological chemistry
A luminescent reporter assay to quantify SORL1 ectodomain shedding and retromer-dependent endosome recycling activity.
Elnaz Fazeli, Asad Jan, Ann-Kathrin Huber, Anne Mette G Jensen, Elham Fazeli, Joel Klein, Kalpana Merchant, Olav M Andersen
Published: 202610.1016/j.jbc.2026.111136
Abstract
Growing evidence suggests that defects in endosomal recycling are a causal mechanism for Alzheimer's disease (AD). Sortilin-like receptor 1 (SORL1) is an endosomal sorting receptor that acts together with the retromer complex to facilitate shuttling…
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