The Journal of biological chemistry
FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly.
Ushma Anand, Amit Bloomberg, Pradip Bhattacharjee, Swarnendu Mukhopadhyay, Binshad Badarudeen, Shivani Ramakrishnan, Uri Ben-David, Tapas K Manna
Published: 202510.1016/j.jbc.2025.111104
Abstract
Uncontrolled centriole duplication leads to centrosome amplification and chromosomal instability, but its underlying mechanism is poorly understood. A new centriole is duplicated from a cartwheel-like structure assembled by Plk4-phosphorylated SCL/TA…
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