The Journal of biological chemistry
TIM-3 inhibition enhances breast tumor progression and metastasis: A paradoxical immune checkpoint response.
Barnali Dolui, Banani Majumdar, Arghya Bandyopadhyay, Kartiki V Desai, Anupam Basu
Published: 202510.1016/j.jbc.2025.111096
Abstract
T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an emerging immune checkpoint receptor. Blocking immune checkpoint signals is a promising strategy for cancer immunotherapy. While TIM-3 blockade is currently under clinical investigation…
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