Journal of autoimmunity
Sera from patients with dermatomyositis and antisynthetase syndrome mediate muscle weakness, impair mitochondrial respiration and induce local cytokine production in muscle tissue.
Cecilia Leijding, Stefano Gastaldello, Tomas Schiffer, Suchada Kaewin, Kristofer M Andreasson, Yi Zhong, Begum Horuluoglu, Maryam Dastmalchi, Antonella Notarnicola, Angeles S Galindo-Feria, Volker M Lauschke, Mattias Carlström, Helene Alexanderson, Ingrid E Lundberg, Daniel C Andersson
Published: 202610.1016/j.jaut.2025.103522
Abstract
OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are systemic autoimmune disorders characterized by skeletal muscle weakness and inflammatory cell infiltrates in muscle tissue. Although circulating systemic factors have been implicated in IIM, it…
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