Journal of autoimmunityHumansTumor Necrosis Factor Receptor SuperfamilyMember 9Alternative SplicingLymphocyte Activation
Alternate splicing converts human CD137 from costimulatory to immunosuppressive function.
Manuel Rojas, Luke S Heuer, Weici Zhang, Nicolle Sweeney, Carolina Ramírez-Santana, Patrick S C Leung, Alvin Lam, Shraddha Kamat, Andrew R Mendelsohn, Manley Huang, Bo Yu, Paulina Ackerman, Qisheng Wei, James W Larrick, Yi-Guang Chen
Published: 202510.1016/j.jaut.2025.103498
Abstract
Human membrane-bound CD137 (mCD137) is a well-known costimulatory molecule; however, it is alternatively spliced into two transcripts (sCD137-1, 2) whose function is not yet known. Here, we show that sCD137 isoforms lack the CRD4 region and form uniq…
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