Journal of advanced research
Distinct effector functions and synergy of CAR mRNA-engineered T cells and macrophages in the clearance of CD19+ leukemia cells.
Liangliang Liao, Cheng Lin, Adrian Kuzmanović, Nan Wang, Alexander Jans, Christian Penners, Kim Ohl, Sandra Johnen, Reka Geczy, Martin Rabel, Samuel Clarke, Aruna Balgi, Christian Liedtke, Matthias Bartneck
Published: 202610.1016/j.jare.2026.01.049
Abstract
INTRODUCTION: Chimeric antigen receptor (CAR) technology represents a groundbreaking advancement in gene therapy. While CAR-T cells are approved for specific types of leukemia, the therapeutic potential of CAR-macrophages remains largely unexplored.…
Preview only. Read the full abstract at the source