Journal of advanced research
Guaianolide dimer KGA-1002 targets GRP94 and triggers unfolded protein response-associated degradation of SKP2/AKT axis as a novel antihepatoma agent.
Qi-Hao Li, Tian-Ze Li, Yong-Cui Wang, Xiao-Yan Huang, Wen-Jing Ma, Feng-Jiao Li, Feng-Dan Huang, Min-Min Hu, Ji-Jun Chen
Published: 202610.1016/j.jare.2026.01.010
Abstract
INTRODUCTION: Hepatocellular carcinoma (HCC) remains a highly lethal malignant tumor with limited treatment options. The guaianolide dimer KGA-1002 exhibited significant inhibitory effects on HCC cells, but the specific target and mechanism remain un…
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