Journal of advanced research
METTL4 enhances GLI1 translation through m6Am modification to promote tumor progression as a therapeutic target for hepatocellular carcinoma.
Weijie Sun, Weiqi Dai, Chaobo Chen, Qian Qiu, Jianqing Chen, Jiaojiao Chen, Yueyue Li, Yuqi Liu, Dengyu Han, Wenhui Mo, Zishu Wang, Yihang Yuan, Xuanfu Xu
Published: 202610.1016/j.jare.2026.01.009
Abstract
INTRODUCTION: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Epigenetic dysregulation, particularly through methyltransferase METTL4, plays a critical role in HCC progression. METTL4 is known to catalyze m6Am methylation…
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