Journal of advanced research
Ursolic acid reduces Aβ-driven aggression via Gab1-mediated autophagy and dorsal hippocampal circuit modulation in Alzheimer's disease.
Guilin Pi, Lijuan Zhang, Huiyang Lei, Tongkai Zhong, Fuqiang Zhang, Yating Lu, Xiaoyuan Qiu, Yaxuan Qi, Yalan Dong, Rui Zhu, Qian Qin, Jing Wang, Alexey Sarapultsev, Shanshan Luo, Xiang Cheng
Published: 202610.1016/j.jare.2025.12.054
Abstract
INTRODUCTION: Aggression is one of the most debilitating neuropsychiatric symptoms in Alzheimer's disease (AD), posing significant challenges for both patients and caregivers. However, the underlying mechanism remains unclear, and effective therapeut…
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