Journal of advanced research
Transforming destructive mechanical cues into therapeutic power: Activation of PIEZO1 and TRPV4 counteracts mechano-induced damage of cellular junctions in Hailey-Hailey disease.
Jiahui Hu, Yuanbo Jia, Fan Feng, Qiang Zhao, Bin Peng, Xi Wang, Huayi Xiong, Feng Xu, Songmei Geng
Published: 202510.1016/j.jare.2025.11.055
Abstract
INTRODUCTION: Hailey-Hailey disease (HHD) is characterized by impaired intracellular calcium transport due to ATP2C1 mutations, leading to defective inter-keratinocyte adhesion and acantholysis, especially under mechanical stimulation, which exacerba…
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