Journal of advanced research
ZUP1 promotes DNA repair and immune evasion to drive olaparib resistance in triple-negative breast cancer.
Shanshan Huang, Yu Qiu, Linyu Wu, Yi Xie, Zhiting He, Yingqing Li, Xinhua Xie
Published: 202510.1016/j.jare.2025.11.038
Abstract
INTRODUCTION: Olaparib resistance limits its therapeutic efficacy in triple-negative breast cancer (TNBC). Exploring the mechanisms underlying olaparib resistance and developing combination strategies are of great clinical significance for improving…
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