Journal of advanced research
Norisoboldine restrains γδT17 cell activation and consequently alleviates psoriasis-like dermatitis in mice by selectively down-regulating glutaminolysis to decrease the level of α-ketoglutarate.
Yue He, Chenxi Li, Junchen Fan, Yanrong Zhu, Yilei Guo, Zhifeng Wei, Yue Dai, Yufeng Xia
Published: 202510.1016/j.jare.2025.10.043
Abstract
INTRODUCTION: Psoriasis, an inflammatory skin disease characterized by aberrant type 17 immunity, is effectively treated with monoclonal antibodies targeting IL-17, though with notable side effects. Given that γδT17 cells represent the primary source…
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