Journal of affective disorders
A head-to-head comparison of gray matter morphological differences between early-onset and middle-to-late-onset depression in a large-scale multi-site cohort.
Keke Fang, Baohong Wen, Liang Liu, Ya Tian, Huiting Yang, Shaoqiang Han, Lianjie Niu, Xianfu Sun
Published: 202610.1016/j.jad.2026.121222
Abstract
Neuroimaging studies have consistently identified structural brain abnormalities in major depressive disorder (MDD). However, the influence of age at onset-a key factor contributing to the structural heterogeneity of MDD-remains unclear. This study p…
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