Journal of affective disorders
Urinary steroid metabolome shows adrenal, gonadal, and neuroactive steroid dysregulation in adolescents with depressive symptoms.
Lars Dinkelbach, Stefan A Wudy, Michaela F Hartmann, Lars Libuda, Manuel Föcker, Johannes Hebebrand, Anke Hinney, Ute Nöthlings, Ute Alexy, Corinna Grasemann, Raphael Hirtz
Published: 202510.1016/j.jad.2025.120867
Abstract
BACKGROUND: Steroid hormone profiles in affective disorders suggest hypothalamic-pituitary-adrenal (HPA) axis dysregulation and may reveal novel therapeutic targets. However, most existing studies focus narrowly on glucocorticoids. This study aims to…
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