Journal of clinical lipidology
Sequencing and functional characterization of SCARB1 variants in subjects with extreme HDL cholesterol levels.
Irene Gracia-Rubio, Asier Benito-Vicente, Itziar Lamiquiz-Moneo, Ana María Bea, Victoria Marco-Benedí, Endika Cabrera-Antón, César Martín, Fernando Civeira, Ana Cenarro
Published: 202510.1016/j.jacl.2025.11.017
Abstract
BACKGROUND: Rare variants in SCARB1, which encodes the high-density lipoprotein (HDL) receptor scavenger receptor class B type 1 (SR-B1), are hypothesized to drive unexplained extreme levels of plasma HDL cholesterol (HDL-C). OBJECTIVE: We sequenced…
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