The Journal of allergy and clinical immunology
Somatic STAT5BN642H mutations shape variable immune landscapes resulting in heterogenous immune diseases.
Sarah Grün, Anne Rensing-Ehl, Tobias Suske, Julian Wolter-Mess, Jonathan Gehrig, Jasmin Mann, Christoph König, Mathias Hauri, Maximilian Heeg, Timothy Ronan Leahy, David Genevieve, Jean-Baptiste Gaillard, Martin Broly, Arnaud Bourdin, Carla Castro
Published: 202510.1016/j.jaci.2025.12.993
Abstract
BACKGROUND: Inborn errors of immunity are traditionally understood as monogenic germline disorders. However, somatic mosaicism can also result in immune-mediated diseases, mimicking inborn errors of immunity. While early postzygotic mosaicism is the…
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