The Journal of allergy and clinical immunology
B-cell lymphocytosis and reprogramming due to biallelic CARD11 mutations.
Sagar Bhattad, Hwi M Gil, Allison Ruchinskas, Jeffrey R Stinson, Aidé Tamara Staines Boone, Rachna Shanbhag Mohite, Jyothi Janardhanan, Neha Singh, Christine Mariskanish, Joseph M Choi, Shamel Basaria, Xiang Ye, Andrew L Snow, Janet G Markle
Published: 202510.1016/j.jaci.2025.12.991
Abstract
BACKGROUND: Adaptive immune responses are tightly controlled by proteins including CARD11 that regulate signaling events downstream of the T- and B-cell receptors. Germline mutations in CARD11 cause several distinct monogenic inborn errors of immunit…
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