The Journal of allergy and clinical immunology
Alpha-gal-specific human IgE promotes both alpha-gal-induced and antigen-independent allergic effector cell activation.
Yinghui Wang, Yugen Zhang, Christa Dudley, Katherine Fitzgerald, Audrey S Carson, Camille M Kapita, Daaniya Rana, Kim Kluckman, Donna Bortner, Dale O Cowley, Christopher R Travis, Julia Vorobiov, Shailesh Choudhary, Christopher L Kepley, Scott P Commins
Published: 202610.1016/j.jaci.2025.12.1007
Abstract
BACKGROUND: In alpha-gal syndrome (AGS), immunoglobulin (Ig)E antibodies form against the glycan galactose-alpha-1,3-galactose (alpha-gal) in mammal products rather than food proteins. Alpha-gal glycolipids and glycoproteins activate human basophils…
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