The Journal of allergy and clinical immunology
Aberrant ceramide accumulation fuels eosinophilic inflammation by promoting eosinophil extracellular trap formation and release in chronic rhinosinusitis with nasal polyps.
Pengda Fang, Mengzhen Wu, Junhai Chen, Wenlong Li, Yurong Bai, Wenyi Chen, Yue Li, Xinyue Wang, Zhenhao Xiao, Tong Wu, Qintai Yang, Yana Zhang
Published: 202510.1016/j.jaci.2025.11.004
Abstract
BACKGROUND: Eosinophilic inflammation represents a hallmark pathologic feature of chronic rhinosinusitis with nasal polyps (CRSwNP). Although ceramides, the central sphingolipid metabolites, are implicated in asthma pathogenesis, their mechanistic co…
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