Percutaneous Orthotopic Transcatheter Tricuspid Valve Replacement for Native Valve Destruction After Endocarditis.

BACKGROUND: Transcatheter tricuspid valve replacement (TTVR) is emerging as an option for treating severe tricuspid regurgitation (TR) in patients at high surgical risk. CASE SUMMARY: A 59-year-old man with torrential TR and right heart failure following Staphylococcus aureus tricuspid valve infective endocarditis and extensive leaflet destruction was successfully treated with orthotopic TTVR using the LuX-Valve Plus system (Jenscare), resulting in significant clinical improvement and favorable right ventricular remodeling. DISCUSSION: The LuX-Valve Plus, delivered via transjugular access, enables optimal coaxial alignment during deployment. Its unique features-leaflet graspers, a septal anchoring mechanism, and a flexible frame-provide stability and preserve right ventricular function, making it suitable for complex tricuspid anatomies. TAKE-HOME MESSAGES: Orthotopic TTVR with the LuX-Valve Plus offers a viable option for patients with severe TR and extensive leaflet destruction, previously considered ineligible for surgical or transcatheter repair. Multimodality imaging is essential for procedural planning and optimal outcomes.