Transcranial microtesla magnetic fields suppress neuroinflammation and neuronal oxidative stress burden.

Neuroinflammation is a major driver of neurodegenerative and psychiatric disease, yet current therapies have limited brain penetration and efficacy. We investigated microtesla magnetic therapy (MMT), a brief transcranial exposure to time-varied electromagnetic fields (TV-EMFs), as a noninvasive approach to modulate neuroimmune inflammation. In human peripheral blood mononuclear cells, MMT suppressed lipopolysaccharide (LPS)-induced TNFα and IL-1β release and reduced NF-κB activation in monocyte and macrophage lines. In rats with intracerebral LPS injection, a model of progressive neuroinflammation, repeated head-localized MMT markedly decreased microgliosis, astrogliosis, and lesion size. In a neuron-immune cell model, MMT reduced cytokine-driven and paraquat-induced oxidative stress, producing both indirect and direct neuroprotection lasting up to 48 h. Collectively, these findings validate transcranial MMT as a promising, noninvasive biophysical therapy for neuroinflammatory conditions. Both acute and repetitive TV-EMF protocols delivered robust anti-inflammatory, antioxidant, and neuroprotective effects, demonstrating the therapeutic potential of precisely modulated EMFs to safely manage neuroinflammation.